Potential Antitumor and Immunological Properties of Acylglucosylsterol from Moringa oleifera (Malunggay) Seeds

Abstract

One of the bioactive compounds that has been isolated from various parts of Moringa oleifera (malunggay) is 3-O-[6’-0O-oleoyl-B-D-glucosyl]-B-sitosterol, generally known as acylglucosylsterol. Isolation of this compound involves solvent fractionation, liquid column chromatography and thin layer chromatography. The isolated compound was tested for its cytotoxic effect on leukemic cells. A cytotoxicity assay, based on blue trypan dye exclusion method, revealed an LC50 of 38 mg/ml. en leukemic cells. Administration of acylglucosylsterol was also found to cause changes in the differential leukocyte counts of ICR strain albino mice injected with 22% bovine serum albumin as immunogen.